1563 Holy Roman Emperor Maximilian II of Austria and his wife Infanta Maria of Spain with their children by Giuseppe Arcimboldi (Schloß Ambras - Innsbruck Austria)
The Habsburgs ruled Spain as well as Austria making this international marriage a marriage of first cousins. She was deeply religious, returning to Spain after Maximilian died to become a nun, but Maximilian was not. Her daughter Anna married King Felipe II of Spain. This Infanta Maria's Wikipedia article is here.