ca. 1500 Lucrezia Borgia portraying Beatrice d'Este by Bartolomeo Veneto (Snite Museum of Art, University of Notre Dame - South Bend, Indiana USA)
Beatrice d'Este (or Lucrezia Borgia) in her stead is portrayed wearing Italian Renaissance day dress. She lived from 1475-1497 so this is either a posthumous portrait or the circa 1500 in the date needs to be taken seriously. Beatrice d'Este's Wikipedia article is here. Lucrezia Borgia, from what I recall, was a pawn in dynastic intrigues who has a possibly undeserved reputation as a poisoner. Thanks to Contardo Padovano for catching the misidentification.
The Wikipedia article for Bartolomeo Veneto is here.
Image made lighter by gogm.